What is Spermidine?

Spermidine is a naturally-occurring polyamine that induces autophagy, your body’s cellular “clean up” and recycling process. Mainly through this mechanism, it targets 9 of the 12 root causes of aging, known as the “Hallmarks of Aging”.

When you are young, you produce 2/3 of your spermidine content needs in your gut biome and body tissues. The final 1/3 comes from your diet. 

As you age, your body’s ability to produce it declines and you become much more reliant on food-derived, supplemental sources.

What Does The Science Say?

Spermidine supplementation in humans has been shown to have several positive effects including protecting brain and heart health, improving hair growth and fullness, and strengthening nails.

There have also been a number of studies in mice showing spermidine’s potential in healthy aging, longevity, and fertility.

Spermidine & The “Hallmarks Of Aging”

According to a landmark paper by Lopez-Otin et al, aging is driven by 12 “hallmarks”. Among them are impaired autophagy, stem cell and mitochondrial dysfunction, inflammation, and gut dysbiosis, which all are known to be reduced by spermidine supplementation.

Spermidine is one of few known compounds thought to reduce or reverse the effects of multiple hallmarks; through its induction of autophagy, in particular, it is thought to impact 9 of the 12 hallmarks. 

Autophagy: Nobel Prize Winning Science

Autophagy, derived from the Greek term meaning “self-eating,” is a crucial cellular clean-out process that removes or recycles damaged cellular components, eliminating damaged parts to maintain health.

This ground-breaking discovery was made by Japanese scientist Yoshinori Ohsumi, whose description of autophagy earned him the Nobel Prize in Physiology or Medicine in 2016. Notably, we are proud to be the only non-Japanese company collaborating with him and his team.